CYBB antibody (C-Term)

Catalog No. ABIN5515414

The Rabbit Polyclonal anti-CYBB antibody is suitable to detect CYBB in samples from Human, Mouse, Rat, Rabbit, Dog, Cow, Guinea Pig and Horse. It has been validated for WB.

Quick Overview for CYBB antibody (C-Term) (ABIN5515414)

Target: CYBB (Cytochrome B-245, beta Polypeptide (CYBB))

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Cow, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYBB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CYBB Antibody

Binding Specificity: C-Term

Sequence: GRPNWDNEFK TIASQHPNTR IGVFLCGPEA LAETLSKQSI SNSESGPRGV

Predicted Reactivity: Cow: 85%, Dog: 93%, Guinea Pig: 77%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CYBB. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CYBB

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CYBB

Target: CYBB (Cytochrome B-245, beta Polypeptide (CYBB))

Alternative Name: CYBB

Background: Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase, neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.

Alias Symbols: AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX

Protein Interaction Partner: IQGAP1, ACTB, UBC, SUMO1, RAC1, NCF4, NCF2, NCF1, CYBA, ACTG1,

Protein Size: 570

Gene ID: 1536

NCBI Accession: NM_000397, NP_000388

UniProt: P04839