CAMLG antibody (C-Term)

Catalog No. ABIN5515470

Product Details anti-CAMLG Antibody

Target: CAMLG (Calcium Modulating Ligand (CAMLG))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAMLG antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LISEKPSQED GNTTEEFDSF RIFRLVGCAL LALGVRAFVC KYLSIFAPFL

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 79%, Rat: 93%, Yeast: 90%

Characteristics: This is a rabbit polyclonal antibody against CAMLG. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CAMLG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CAMLG

Target: CAMLG (Calcium Modulating Ligand (CAMLG))

Alternative Name: CAMLG (CAMLG Products)

Synonyms: MGC53900 antibody, CAML antibody, AI385748 antibody, Camlg antibody, Caml antibody, calcium modulating ligand L homeolog antibody, calcium modulating ligand antibody, camlg.L antibody, CAMLG antibody, camlg antibody, Caml antibody, Camlg antibody

Background: The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

Alias Symbols: CAMLG, CAML,

Protein Interaction Partner: KCNA2, TMUB1, TNFRSF13B, UBC, RNF122, PKHD1, EGFR, PPIB, IER3,

Protein Size: 296

Gene ID: 819

NCBI Accession: NP_001736

UniProt: P49069

Pathways: EGFR Signaling Pathway