ANO1 antibody (C-Term)

Catalog No. ABIN5515653

This Rabbit Polyclonal antibody specifically detects ANO1 in WB. It exhibits reactivity toward Human.

Quick Overview for ANO1 antibody (C-Term) (ABIN5515653)

Target: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANO1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ANO1 Antibody

Binding Specificity: C-Term

Purpose: ANO1 Antibody - C-terminal region

Sequence: LMVELFMREE QDKQQLLETW MEKERQKDEP PCNHHNTKAC PDSLGSPAPS

Characteristics: This is a rabbit polyclonal antibody against ANO1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ANO1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP72448-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ANO1

Target: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Alternative Name: ANO1

Background:

Background Information: ANO1 is a calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. It is required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. It acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.

Alternative Symbols: DOG1, TAOS2, ORAOV2, TMEM16A

Molecular Weight: 108kDa

Gene ID: 55107

NCBI Accession: NP_060513

UniProt: Q5XXA6