AIPL1 antibody (C-Term)

Catalog No. ABIN5515809

This Rabbit Polyclonal antibody specifically detects AIPL1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Horse, Pig and Rabbit.

Quick Overview for AIPL1 antibody (C-Term) (ABIN5515809)

Target: AIPL1 (Aryl Hydrocarbon Receptor Interacting Protein-Like 1 (AIPL1))

Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIPL1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-AIPL1 Antibody

Binding Specificity: C-Term

Sequence: DLDELQKEPQ PLVFVIELLQ VDAPSDYQRE TWNLSNHEKM KAVPVLHGEG

Predicted Reactivity: Cow: 79%, Horse: 86%, Human: 100%, Mouse: 77%, Pig: 86%, Rabbit: 79%, Rat: 77%

Characteristics: This is a rabbit polyclonal antibody against AIPL1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human AIPL1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AIPL1

Target: AIPL1 (Aryl Hydrocarbon Receptor Interacting Protein-Like 1 (AIPL1))

Alternative Name: AIPL1

Background: Leber congenital amaurosis (LCA) is the most severe inherited retinopathy with the earliest age of onset and accounts for at least 5 % of all inherited retinal diseases. Affected individuals are diagnosed at birth or in the first few months of life with nystagmus, severely impaired vision or blindness and an abnormal or flat electroretinogram. The photoreceptor/pineal-expressed gene, AIPL1, encoding aryl-hydrocarbon interacting protein-like 1, is located within the LCA4 candidate region. The encoded protein contains three tetratricopeptide motifs, consistent with chaperone or nuclear transport activity. Mutations in this gene may cause approximately 20 % of recessive LCA. Alternative splicing results in multiple transcript variants.

Alias Symbols: LCA4, AIPL2

Protein Size: 270

Gene ID: 23746

NCBI Accession: NM_001285403, NP_001272332

UniProt: F1T0C4