CDC14B antibody (N-Term)

Catalog No. ABIN5515888

The Rabbit Polyclonal anti-CDC14B antibody is suitable to detect CDC14B in samples from Human. It has been validated for WB.

Quick Overview for CDC14B antibody (N-Term) (ABIN5515888)

Target: CDC14B (CDC14 Cell Division Cycle 14B (CDC14B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDC14B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CDC14B Antibody

Binding Specificity: N-Term

Purpose: CDC14B Antibody - N-terminal region

Sequence: RCSSTSPGVK KIRSSTQQDP RRRDPQDDVY LDITDRLCFA ILYSRPKSAS

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CDC14B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP80337-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CDC14B

Target: CDC14B (CDC14 Cell Division Cycle 14B (CDC14B))

Alternative Name: CDC14B

Background:

Background Information: The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.

Gene Name: cell division cycle 14B

Alternative Symbols: CDC14B3, Cdc14B1, Cdc14B2, hCDC14B

Protein Name: dual specificity protein phosphatase CDC14B

Molecular Weight: 53 kDa

Gene ID: 8555

NCBI Accession: NP_001070649

UniProt: O60729