MAP2K4 antibody (C-Term)

Catalog No. ABIN5516102

This anti-MAP2K4 antibody is a Rabbit Polyclonal antibody detecting MAP2K4 in WB. Suitable for Human.

Quick Overview for MAP2K4 antibody (C-Term) (ABIN5516102)

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP2K4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAP2K4 Antibody

Binding Specificity: C-Term

Sequence: NLKIIHRDIK PSNILLDRSG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA

Characteristics: This is a rabbit polyclonal antibody against MAP2K4. It was validated on Western Blot.

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MAP2K4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAP2K4

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Alternative Name: MAP2K4

Background: This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants.

Alias Symbols: JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1

Protein Interaction Partner: UBC, EGFR, GEMIN5, MAP3K5, MAP3K1, GCH1, MAPK10, MAPK9, MAPK8, MAPK1, ARRB2, ARRB1, MAP3K7, RBBP8, JUN, MAP2K7, APP, MAP3K2, MAPK14, AKT1, LRRK2, MAP2K4, MAP2K6, MAP3K4, MAP3K3, PML, BLNK, ITCH, MAPK8IP3, ZAK, SPAG9, TRIB1, MAP3K14, CFLAR, MAPK12, EFNA4,

Protein Size: 399

Gene ID: 6416

NCBI Accession: NM_003010, NP_003001

UniProt: P45985

Pathways: MAPK Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling