DPM2 antibody (Middle Region)

Catalog No. ABIN5516306

The Rabbit Polyclonal anti-DPM2 antibody (ABIN5516306) specifically detects DPM2 in WB. The antibody is reactive with Human samples.

Quick Overview for DPM2 antibody (Middle Region) (ABIN5516306)

Target: DPM2 (Dolichyl-Phosphate Mannosyltransferase Polypeptide 2, Regulatory Subunit (DPM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPM2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DPM2 Antibody

Binding Specificity: Middle Region

Sequence: DSQHVIHKYF LPRAYAVAIP LAAGLLLLLF VGLFISYVML KTKRVTKKAQ

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DPM2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DPM2

Target: DPM2 (Dolichyl-Phosphate Mannosyltransferase Polypeptide 2, Regulatory Subunit (DPM2))

Alternative Name: DPM2

Background: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1.

Alias Symbols: CDG1U

Protein Size: 84

Gene ID: 8818

NCBI Accession: NM_003863, NP_003854

UniProt: O94777

Pathways: Inositol Metabolic Process