NLRP12 antibody (N-Term)

Catalog No. ABIN5516341

The Rabbit Polyclonal anti-NLRP12 antibody is suitable to detect NLRP12 in samples from Human, Mouse, Rat, Cow, Pig and Dog. It has been validated for WB.

Quick Overview for NLRP12 antibody (N-Term) (ABIN5516341)

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NLRP12 Antibody

Binding Specificity: N-Term

Purpose: NLRP12 Antibody - N-terminal region

Sequence: LEVSLVTPRK DPQETYRDYV RRKFRLMEDR NARLGECVNL SHRYTRLLLV

Predicted Reactivity: Cow: 100%, Dog: 90%, Human: 100%, Mouse: 77%, Pig: 100%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against NLRP12. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human NLRP12

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64968-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for NLRP12

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Alternative Name: NLRP12

Background:

Background Information: This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.

Gene Name: NLR family, pyrin domain containing 12

Alternative Symbols: RNO, PAN6, RNO2, FCAS2, NALP12, PYPAF7, CLR19.3

Protein Name: NACHT, LRR and PYD domains-containing protein 12

Molecular Weight: 116kDa

Gene ID: 91662

NCBI Accession: NP_653288

UniProt: P59046

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome