MR1 antibody (N-Term)

Catalog No. ABIN5516857

The Rabbit Polyclonal anti-MR1 antibody is suitable to detect MR1 in samples from Human. It has been validated for WB.

Quick Overview for MR1 antibody (N-Term) (ABIN5516857)

Target: MR1 (Major Histocompatibility Complex, Class I-Related (MR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MR1 Antibody

Binding Specificity: N-Term

Purpose: MR1 Antibody - N-terminal region

Sequence: RTHSLRYFRL GVSDPIHGVP EFISVGYVDS HPITTYDSVT RQKEPRAPWM

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MR1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP78052-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for MR1

Target: MR1 (Major Histocompatibility Complex, Class I-Related (MR1))

Alternative Name: MR1

Background:

Background Information: MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome.

Gene Name: major histocompatibility complex, class I-related

Alternative Symbols: HLALS

Protein Name: major histocompatibility complex class I-related gene protein

Molecular Weight: 39 kDa

Gene ID: 3140

NCBI Accession: NP_001181928

UniProt: Q95460

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints