FBXW5 antibody (N-Term)

Catalog No. ABIN5516989

The Rabbit Polyclonal anti-FBXW5 antibody is suitable to detect FBXW5 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for FBXW5 antibody (N-Term) (ABIN5516989)

Target: FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FBXW5 Antibody

Binding Specificity: N-Term

Sequence: NDLTISLLHS ADMRPYNWSY TQFSQFNKDD SLLLASGVFL GPHNSSSGEI

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rat: 93%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against FBXW5. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human FBXW5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FBXW5

Target: FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

Alternative Name: FBXW5

Background: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.

Alias Symbols: FBXW5, FBW5, PP3971,

Protein Interaction Partner: KRT40, KRTAP9-4, ADAMTSL4, CUL1, UBC, TRIM27, KRT31, NOTCH2NL, KRTAP10-3, KRTAP10-8, CUL3, SKP1, TNFAIP8L1, TSC2, DLC1, HSP90AA1, NEDD8, MAP3K7, CUL4A, REST, MYB, DDB1, UBE2R2, SASS6, PLK4, CDC20, WDR20, KRTAP4-12, MDFI, TSC1, NLK,

Protein Size: 566

Gene ID: 54461