NAGLU antibody (N-Term)

Catalog No. ABIN5517087

This Rabbit Polyclonal antibody specifically detects NAGLU in WB. It exhibits reactivity toward Human, Cow, Dog and Pig.

Quick Overview for NAGLU antibody (N-Term) (ABIN5517087)

Target: NAGLU (N-Acetylglucosaminidase, alpha (NAGLU))

Reactivity: Human, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAGLU antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NAGLU Antibody

Binding Specificity: N-Term

Purpose: NAGLU Antibody - N-terminal region

Sequence: GVLLLAGAGG AAGDEAREAA AVRALVARLL GPGPAADFSV SVERALAAKP

Predicted Reactivity: Cow: 83%, Dog: 92%, Human: 100%, Pig: 79%

Characteristics: This is a rabbit polyclonal antibody against ANAG. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human NAGLU

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58644-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for NAGLU

Target: NAGLU (N-Acetylglucosaminidase, alpha (NAGLU))

Alternative Name: NAGLU

Background:

Background Information: This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate.

Gene Name: N-acetylglucosaminidase, alpha

Alternative Symbols: NAG, CMT2V, MPS3B, UFHSD, MPS-IIIB

Protein Name: Alpha-N-acetylglucosaminidase

Molecular Weight: 81kDa

Gene ID: 4669

NCBI Accession: NP_000254

UniProt: P54802

Pathways: Glycosaminoglycan Metabolic Process