PELI2 antibody (AA 118-420)

Catalog No. ABIN7870263

The Rabbit Polyclonal anti-PELI2 antibody is suitable to detect PELI2 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, FACS, IF and IHC (p).

Quick Overview for PELI2 antibody (AA 118-420) (ABIN7870263)

Target: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PELI2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PELI2 Antibody

Binding Specificity: AA 118-420

Purpose: Pellino 2 Antibody / PELI2

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids D118-D420) was used as the immunogen for the Pellino 2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Pellino 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Pellino 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PELI2

Target: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Alternative Name: Pellino 2

Background: Protein pellino homolog 2 is a protein that in humans is encoded by the PELI2 gene. PELI2 is a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. It may be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. And it can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

UniProt: Q9HAT8

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades