PDP antibody (N-Term)

Catalog No. ABIN5517423

This Rabbit Polyclonal antibody specifically detects PDP in WB. It exhibits reactivity toward Human.

Quick Overview for PDP antibody (N-Term) (ABIN5517423)

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDP Antibody

Binding Specificity: N-Term

Sequence: SSSYIPQSRL RYTPHPAYAT FCRPKENWWQ YTQGRRYAST PQKFYLTPPQ

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PDP1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDP

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Alternative Name: PDP1

Background: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Alias Symbols: PDH, PDP, PDPC, PPM2C

Protein Size: 537

Gene ID: 54704

NCBI Accession: NM_001161779, NP_001155251

UniProt: Q9P0J1