PKDCC antibody (N-Term)

Catalog No. ABIN5517602

The Rabbit Polyclonal anti-PKDCC antibody (ABIN5517602) specifically detects PKDCC in WB. The antibody is reactive with Human samples.

Quick Overview for PKDCC antibody (N-Term) (ABIN5517602)

Target: PKDCC (Protein Kinase Domain Containing, Cytoplasmic Homolog (Mouse) (PKDCC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKDCC antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PKDCC Antibody

Binding Specificity: N-Term

Purpose: PKDCC Antibody - N-terminal region

Sequence: GGRGELARQI RARYEEVQRY SRGGPGPGAG RPERRRLMDL APGGPGLPRP

Predicted Reactivity: Cow: 100%, Dog: 78%, Human: 100%, Mouse: 100%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PKDCC

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP62899-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PKDCC

Target: PKDCC (Protein Kinase Domain Containing, Cytoplasmic Homolog (Mouse) (PKDCC))

Alternative Name: PKDCC

Background:

Background Information: Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29. Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation. May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane.

Gene Name: protein kinase domain containing, cytoplasmic

Alternative Symbols: Vlk, RLSDF, SGK493

Protein Name: Extracellular tyrosine-protein kinase PKDCC

Molecular Weight: 54 kDa

Gene ID: 91461

NCBI Accession: NP_612379

UniProt: Q504Y2