PYDC1 antibody (N-Term)

Catalog No. ABIN5517612

This Rabbit Polyclonal antibody specifically detects PYDC1 in WB. It exhibits reactivity toward Human, Saccharomyces cerevisiae, Cow, Dog, Goat, Guinea Pig and Horse.

Quick Overview for PYDC1 antibody (N-Term) (ABIN5517612)

Target: PYDC1 (PYD (Pyrin Domain) Containing 1 (PYDC1))

Reactivity: Human, Saccharomyces cerevisiae, Cow, Dog, Goat, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PYDC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PYDC1 Antibody

Binding Specificity: N-Term

Purpose: PYDC1 Antibody - N-terminal region

Sequence: REAILKVLEN LTPEELKKFK MKLGTVPLRE GFERIPRGAL GQLDIVDLTD

Predicted Reactivity: Cow: 83%, Dog: 83%, Goat: 83%, Guinea Pig: 85%, Horse: 83%, Human: 100%, Yeast: 77%

Characteristics: This is a rabbit polyclonal antibody against PYDC1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human PYDC1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55560-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PYDC1

Target: PYDC1 (PYD (Pyrin Domain) Containing 1 (PYDC1))

Alternative Name: PYDC1

Background:

Background Information: PYDC1 associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro- caspase-1 activation. It suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.

Gene Name: PYD (pyrin domain) containing 1

Alternative Symbols: ASC2, POP1, PYC1, cPOP1

Protein Name: Pyrin domain-containing protein 1

Molecular Weight: 9kDa

Gene ID: 260434

NCBI Accession: NP_690865

UniProt: Q8WXC3