PYDC1 antibody (N-Term)

Catalog No. ABIN5517612

Product Details anti-PYDC1 Antibody

Target: PYDC1 (PYD (Pyrin Domain) Containing 1 (PYDC1))

Binding Specificity: N-Term

Reactivity: Human, Saccharomyces cerevisiae, Cow, Dog, Goat, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PYDC1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: REAILKVLEN LTPEELKKFK MKLGTVPLRE GFERIPRGAL GQLDIVDLTD

Predicted Reactivity: Cow: 83%, Dog: 83%, Goat: 83%, Guinea Pig: 85%, Horse: 83%, Human: 100%, Yeast: 77%

Characteristics: This is a rabbit polyclonal antibody against PYDC1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human PYDC1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PYDC1

Target: PYDC1 (PYD (Pyrin Domain) Containing 1 (PYDC1))

Alternative Name: PYDC1 (PYDC1 Products)

Synonyms: ASC2 antibody, POP1 antibody, PYC1 antibody, pyrin domain containing 1 antibody, PYDC1 antibody

Background: PYDC1 associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro- caspase-1 activation. It suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.

Alias Symbols: PYDC1, ASC2, ASCI, POP1, PYC1,

Protein Interaction Partner: WDR82,

Protein Size: 89

Gene ID: 260434

NCBI Accession: NP_690865

UniProt: Q8WXC3