Stanniocalcin 2 antibody (N-Term)

Catalog No. ABIN5532193

This anti-Stanniocalcin 2 antibody is a Rabbit Polyclonal antibody detecting Stanniocalcin 2 in WB and IHC (p). Suitable for Human and Mouse.

Quick Overview for Stanniocalcin 2 antibody (N-Term) (ABIN5532193)

Target: Stanniocalcin 2 (STC2)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Stanniocalcin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Stanniocalcin 2 Antibody

Binding Specificity: AA 16-46, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This Stanniocalcin-2 (STC2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human Stanniocalcin-2 (STC2).

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Stanniocalcin 2

Target: Stanniocalcin 2 (STC2)

Alternative Name: Stanniocalcin-2

Background: STC2 is a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression is induced by estrogen and altered in some breast cancers.

Molecular Weight: 33 kDa

Gene ID: 8614

UniProt: O76061

Pathways: Hormone Activity, ER-Nucleus Signaling, SARS-CoV-2 Protein Interactome