KDM5B antibody (N-Term)

Catalog No. ABIN5537034

The Rabbit Polyclonal anti-KDM5B antibody is suitable to detect KDM5B in samples from Mouse. It has been validated for WB.

Quick Overview for KDM5B antibody (N-Term) (ABIN5537034)

Target: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM5B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KDM5B Antibody

Binding Specificity: AA 192-224, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This JARID1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-224 amino acids from the N-terminal region of human JARID1B.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for KDM5B

Target: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Alternative Name: JARID1B

Background: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.

Molecular Weight: 176 kDa

Gene ID: 10765

UniProt: Q9UGL1

Pathways: Warburg Effect