C3 antibody

Catalog No. ABIN5540070

The Rabbit Polyclonal anti-C3 antibody is suitable to detect C3 in samples from Pig. It has been validated for FACS.

Quick Overview for C3 antibody (ABIN5540070)

Target: C3 (Complement Component 3 (C3))

Reactivity: Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C3 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Product Details anti-C3 Antibody

Specificity: The polyclonal antibody recognizes Pig complement component C3.

Purification: Purified

Immunogen: Purified Pig C3

Isotype: Ig Fraction

Application Details

Application Notes: Flow Cytometry: Use 1/50 as a typical starting working dilution. Positive Control: Red Blood Cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 0.02 % Sodium Azide Stabilizers: 0.1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for C3

Target: C3 (Complement Component 3 (C3))

Alternative Name: complement c3

Background: The complement system is an important part of the humoral response in innate immunity, consisting of three different pathways. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. The complement factor C3 consists of an alpha- and a beta-chain. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/mL. An inherited deficiency of C3 predisposes the person to frequent assaults of bacterial infections. In ulcerative colitis, and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by certain enzymes results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b, C3c, C3dg and C3f.

UniProt: P01025

Pathways: Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling