NGFR antibody (AA 1-160) (Biotin)
Quick Overview for NGFR antibody (AA 1-160) (Biotin) (ABIN5540156)
Target
See all NGFR AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Binding Specificity
- AA 1-160
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Specificity
- This antibody recognizes CD271/NGFR, a 75 kDa transmembrane glycoprotein of the TNFR superfamily. The epitope is localized within ammino acids 1 - 160.
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Immunogen
- Purified CD271 protein isolated from human melanoma cell line A875
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Isotype
- IgG1
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Application Notes
- Indirect immunofluorescence analysis by Flow cytometry: 1:200 as starting point.
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Restrictions
- For Research Use only
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Format
- Liquid
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Storage Comment
- Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
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Expiry Date
- 12 months
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- NGFR (Nerve Growth Factor Receptor (NGFR))
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Alternative Name
- cd271,ngfr
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Background
- CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.
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UniProt
- P08138
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Pathways
- NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
Target
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