Cathepsin S antibody (AA 17-331)

Catalog No. ABIN5540225

This Mouse Monoclonal antibody specifically detects Cathepsin S in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for Cathepsin S antibody (AA 17-331) (ABIN5540225)

Target: Cathepsin S (CTSS)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cathepsin S antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: AT1F9

Product Details anti-Cathepsin S Antibody

Binding Specificity: AA 17-331

Specificity: This antibofy recognizes Human CTSS. Other species not tested.

Purification: Affinity Chromatography on Protein A

Immunogen: Recombinant human CTSS (17-331aa) purified from E. coli

Isotype: IgG2b

Application Details

Application Notes: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution: 1/500.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Cathepsin S

Target: Cathepsin S (CTSS)

Alternative Name: cathepsin s

Background: CTSS (Cathepsin S) is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, CTSS is expressed in some epithelial cells. In contrast, cortical thymic epithelial cells do not express CTSS. Normal epidermal keratinocytes do not express CTSS. However, level of CTSS is elevated in psoriatic keratinocytes due to stimulation by proinflammatory factors. CTSS can function as an elastase over a broad pH range in alveolar macrophages.

UniProt: P25774

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades