Cyclin H antibody (AA 1-323)

Catalog No. ABIN5540277

The Mouse Monoclonal anti-Cyclin H antibody is suitable to detect Cyclin H in samples from Human. It has been validated for WB and EIA.

Quick Overview for Cyclin H antibody (AA 1-323) (ABIN5540277)

Target: Cyclin H (CCNH)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cyclin H antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: AT3G6

Product Details anti-Cyclin H Antibody

Binding Specificity: AA 1-323

Purification: Protein-A affinity chromatography

Immunogen: Recombinant human Cyclin H (1-323aa) purified from E.coli.

Isotype: IgG2b

Application Details

Application Notes: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution for Western blot analysis is 1:1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. In Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Cyclin H

Target: Cyclin H (CCNH)

Alternative Name: cyclin h

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kises. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordition of each mitotic event. This cyclin forms a complex with CDK7 kise and ring finger protein MAT1. The kise complex is able to phosphorylate CDK2 and CDC2 kises, thus functions as a CDK-activating kise (CAK). This cyclin and its kise partner are components of TFIIH, as well as R polymerase II protein complexes. They participate in two different transcriptiol regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.

UniProt: P51946

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases, M Phase