NCOA1 antibody (pSer75)

Catalog No. ABIN5540512

The Rabbit Polyclonal anti-NCOA1 antibody (ABIN5540512) specifically detects NCOA1 in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for NCOA1 antibody (pSer75) (ABIN5540512)

Target: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NCOA1 Antibody

Binding Specificity: pSer75

Specificity: The antibody detects endogenous level of Src only when phosphorylated at serine 75.

Purification: Affinity chromatography using epitope-specific peptide

Immunogen: Peptide sequence around phosphorylation site of serine 75 (V-T-S(p)-P-Q) derived from Human Src (KLH-conjugated)

Application Details

Application Notes: Western blot: 1:500~1:1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for NCOA1

Target: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Alternative Name: src1

Background: Proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme.

UniProt: P12931

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha