CCR2 antibody

Catalog No. ABIN5540857

The Mouse Monoclonal anti-CCR2 antibody (Clone 7A7) (ABIN5540857) specifically detects CCR2 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for CCR2 antibody (ABIN5540857)

Target: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCR2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 7A7

Product Details anti-CCR2 Antibody

Specificity: This antibody detects

Purification: Protein G

Immunogen: DNA vaccine

Isotype: IgG2a

Application Details

Application Notes: Immunohistochemistry on paraffin sections: 4-8-μg/mL (1/50-1/100) Pretreatment with proteinase K required.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline pH 7.2 (PBS) Preservatives: 0.1 % Kathon Stabilizers: 5 mg/mL bovine serum albumin (BSA)

Storage: 4 °C,-20 °C

Storage Comment: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CCR2

Target: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Alternative Name: cd192,ccr2

Background: CCR2B is a 374 amino acid protein that belongs to the G - protein coupled receptor 1 family with seven transmembrane domains. It mediates the chemotactic properties of monocyte chemoattractant protein 1 (MCP - 1) which is secreted by endothelial and epithelial cells, vascular smooth muscle and hematopoietic cells. MCP - 1 is a potent chemoattractant for monocytes and lymphocytes. It is responsible for monocyte infiltration in a variety of chronic inflammatory diseases.

UniProt: P41597

Pathways: cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process