NCR1 antibody (Biotin)

Catalog No. ABIN5540952

The Rat Monoclonal anti-NCR1 antibody is suitable to detect NCR1 in samples from Mouse. It has been validated for FACS.

Quick Overview for NCR1 antibody (Biotin) (ABIN5540952)

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This NCR1 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS)

Clone: 29A1-4

Product Details anti-NCR1 Antibody (Biotin)

Specificity: This antibody (clone 29A1.4) recognizes natural killer cell p46 related protein (NKp46) also known as CD335. Staining is not strain specific and the antibody has been used to stain C57BL/6, SJL, CBA/CA and BALB/c Mouse strains. Clone 29A1.4 also activates NK cells in vitro. It does not deplete NK cells in vivo. Species: Mouse.

Immunogen: NKP46-IgG1 Fc fusion protein

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry: Use 10 μL of 1/5-1/10 diluted antibody to label 10 6 cells in 100 μL.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for NCR1

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Alternative Name: cd335,nkp46

Background: CD335 is uniquely expressed by resting and activated natural killer (NK) cells, but no expression of CD335 has been detected on B cells, T cells, monocytes or granulocytes. It is a major NK cell lysis receptor for autologous pathogen-infected and tumor target cells during natural cytotoxicity responses. Ligands of CD335 include viral hemagglutinins (HAs) and heparan sulfate proteoglycans (HSPGs) on the surface of tumor cells.

UniProt: Q8C567

Pathways: Regulation of Leukocyte Mediated Immunity