TERT antibody (AA 627-656)

Catalog No. ABIN5540961

The Rabbit Polyclonal anti-TERT antibody is suitable to detect TERT in samples from Human. It has been validated for WB, FACS, IF, ICC and IHC (p).

Quick Overview for TERT antibody (AA 627-656) (ABIN5540961)

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TERT antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TERT Antibody

Binding Specificity: AA 627-656

Specificity: This antibody detects Human TERT at center. Other species not tested.

Purification: Ammonium Sulfate Precipitation

Immunogen: KLH conjugated synthetic peptide selected from the Center region of Human TERT.

Application Details

Application Notes: Immunofluorescence: 1/10-1/50. Western blot: 1/1000, Flow Cytometry: 1/10-1/50. Immunohistochemistry on Paraffin Sections: 1/100.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS Preservatives: 0.09 % (W/V) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for TERT

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Alternative Name: tert

Background: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.

UniProt: O14746

Pathways: Telomere Maintenance