FUBP1 antibody (AA 279-448)

Catalog No. ABIN5541255

The Mouse Monoclonal anti-FUBP1 antibody is suitable to detect FUBP1 in samples from Human. It has been validated for WB, IF, ICC and EIA.

Quick Overview for FUBP1 antibody (AA 279-448) (ABIN5541255)

Target: FUBP1 (Far Upstream Element (FUSE) Binding Protein 1 (FUBP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FUBP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Enzyme Immunoassay (EIA)

Clone: AT14F5

Product Details anti-FUBP1 Antibody

Binding Specificity: AA 279-448

Purification: Protein-A affinity chromatography

Immunogen: Recombinant human FUBP1 (279-448aa) purified from E.coli.

Isotype: IgG2b

Application Details

Application Notes: The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. In Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for FUBP1

Target: FUBP1 (Far Upstream Element (FUSE) Binding Protein 1 (FUBP1))

Alternative Name: fubp1

Background: FUBP1 is a transcriptiol regulator and fulfills an important function in the precise control of c-myc transcription. The c-Myc protein is a transcription factor which regulates the transcription of many different target genes that play a role in proliferation, cell cycle progression, differentiation, apoptosis and cell metabolism. Consequently, FUBP1 is also involved in the regulation of proliferation and differentiation, as confirmed by different experimental approaches. Knockdown of FUBP1 or expression of a domint-negative FUBP1 (D-binding domain lacking effector activity) led to proliferation arrest in U2OS and Saos-2 osteosarcoma cells due to reduced c-myc expression.

UniProt: Q96AE4