MAPT antibody (pSer202)

Catalog No. ABIN5541354

The Rabbit Polyclonal anti-MAPT antibody is suitable to detect MAPT in samples from Human, Rat and Mouse. It has been validated for WB.

Quick Overview for MAPT antibody (pSer202) (ABIN5541354)

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPT antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAPT Antibody

Binding Specificity: pSer202

Specificity: The antibody detects endogenous levels of Tau only when phosphorylated at serine 202.

Purification: Affinity chromatography using epitope-specific peptide

Immunogen: Peptide sequence around phosphorylation site of serine 202(P-G-S(p)-P-G) derived from Human Tau (KLH-conjugated)

Application Details

Application Notes: Western blot: 1:500~1:1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Alternative Name: mapt,tau

Background: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

UniProt: P10636

Pathways: MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size