TBX2 antibody (AA 554-702)

Catalog No. ABIN5541456

The Mouse Monoclonal anti-TBX2 antibody is suitable to detect TBX2 in samples from Human. It has been validated for WB, IP and IHC (p).

Quick Overview for TBX2 antibody (AA 554-702) (ABIN5541456)

Target: TBX2 (T-Box 2 (TBX2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TBX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4D6

Product Details anti-TBX2 Antibody

Binding Specificity: AA 554-702

Purification: Purified

Immunogen: Derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with a GST fusion protein corresponding to residues 554-702 of Human TBX2.

Isotype: IgG1

Application Details

Application Notes: Western blot. Immunoprecipitation. Immunohistochemistry on Paraffin Sections.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for TBX2

Target: TBX2 (T-Box 2 (TBX2))

Alternative Name: tbx2

Background: T-box transcription factor TBX2 is a protein that in humans is encoded by the TBX2 gene and with subcellulair location in the nucleus. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. In melanocytic cell types, expression of the T-box 2 gene is regulated by the Microphthalmia-associated transcription factor The oncogene TBX2 is a cooperating factor in transformation of pocket protein deficient MEFs. TBX2 downregulates the p53/p21CIP1 pathway both in wild-type and pocket protein deficient MEFs. Tissue specificity: expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.

UniProt: Q13207

Pathways: p53 Signaling