CD46 antibody

Catalog No. ABIN5541989

This Rat Monoclonal antibody specifically detects CD46 in WB, FACS, IF, ICC and EIA. It exhibits reactivity toward Mouse and Rat.

Quick Overview for CD46 antibody (ABIN5541989)

Target: CD46

Reactivity: Mouse, Rat

Host: Rat

Clonality: Monoclonal

Conjugate: This CD46 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC), Enzyme Immunoassay (EIA)

Clone: MM10

Product Details anti-CD46 Antibody

Specificity: The monoclonal antibody MM10 recognizes membrane cofactor protein (MCP), also known as CD46.

Purification: Purified

Immunogen: Mouse CD46-human Fc fusion protein.

Isotype: IgG2a

Application Details

Application Notes: Immuno Assays (Detector) Positive Control: Rat CD46 or Mouse CD46 variant as coating on a micro titer plate. Western blot (Researcher data). Flow Cytometry (Researcher data) Immunefluorescence Immuno histochemistry on Frozen Sections The typical starting working dilution is 1/50.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 0.02 % Sodium Azide Stabilizers: 0.1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD46

Target: CD46

Alternative Name: cd46,mcp

Background: MCP is a type I membrane glycoprotein that consists of four isoforms i.e. two C-isoforms (51-58 kDa) and two BC isoforms (59-68 kDa) which arise by alternative splicing of a single CD46 gene. Membrane cofactor protein is expressed on every cell and tissue, with the exception of erythrocytes. Membrane cofactor protein serves to down-regulate the activation of complement on host tissue. MCP is a cofactor for factor 1-mediated cleavage of C3b and C4b and this way serves to protect the host cell against autologous attack. MCP is a receptor for several pathogens including measles virus, group A Streptococcus pyogenes and pathogenic Neisseria.

UniProt: O88174

Pathways: Regulation of Actin Filament Polymerization