CD46 antibody

Catalog No. ABIN5541990

The Mouse Monoclonal anti-CD46 antibody has been validated for WB, IF, ICC, IHC (fro) and EIA. It is suitable to detect CD46 in samples from Rat.

Quick Overview for CD46 antibody (ABIN5541990)

Target: CD46

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD46 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: MM-1

Product Details anti-CD46 Antibody

Specificity: The monoclonal antibody MM.1 recognizes CD46, also known as membrane cofactor protein.

Purification: Purified

Isotype: IgG1

Application Details

Application Notes: Western blot: Rat testis lysate, non-reducing conditions, band size 38 kDa (Ref.1,4). Immuno Assays (Ref.1). Immunofluorescence (Ref.2-4). Immunohistochemistry on Frozen Sections (Ref.1-3). The typical starting working dilution is 1/50.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Buffer System: PBS Stabilizers: 0.1 % BSA

Storage: 4 °C

Storage Comment: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD46

Target: CD46

Alternative Name: cd46,mcp

Background: An immunohistological survey of rat tissues revealed that CD46 is expressed only in the testis and epididymis of adult rats more specifically, only by spermatozoa and late spermatozoal precursors. In contrast, in humans, CD46 is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to down-regulate the activation of complement on host tissue. It functions as a cofactor by binding to C3b and C4b. Binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. In human, it also serves as a receptor for measles virus. Two isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. The isoforms differ in the length. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)).

UniProt: Q9Z0M4

Pathways: Regulation of Actin Filament Polymerization