MMP2 antibody (AA 9-140)

Catalog No. ABIN5542435

This anti-MMP2 antibody is a Mouse Monoclonal antibody detecting MMP2 in WB, ELISA and FACS. Suitable for Human and Mouse.

Quick Overview for MMP2 antibody (AA 9-140) (ABIN5542435)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This MMP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 2B11E6

Product Details anti-MMP2 Antibody

Binding Specificity: AA 9-140

Purpose: MMP2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human MMP2 (AA: 9-140) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Alternative Name: MMP2

Background: This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 73.8 kDa

Gene ID: 4313

UniProt: P08253

Pathways: Activation of Innate immune Response