p130 antibody (AA 939-1139)

Catalog No. ABIN5542553

This Mouse Monoclonal antibody specifically detects p130 in ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for p130 antibody (AA 939-1139) (ABIN5542553)

Target: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This p130 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 2C8A8

Product Details anti-p130 Antibody

Binding Specificity: AA 939-1139

Purpose: RBL2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human RBL2 (AA: 939-1139) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for p130

Target: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Alternative Name: RBL2

Background: RBL2 is a Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Molecular Weight: 128.4 kDa

Gene ID: 5934

UniProt: Q08999

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases