HDAC7 antibody (N-Term)

Catalog No. ABIN5557306

The Rabbit Monoclonal anti-HDAC7 antibody is suitable to detect HDAC7 in samples from Human. It has been validated for WB, IHC (p), IF, FACS, ICC and IHC (fro).

Quick Overview for HDAC7 antibody (N-Term) (ABIN5557306)

Target: HDAC7 (Histone Deacetylase 7 (HDAC7))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HDAC7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 3H7

Product Details anti-HDAC7 Antibody

Binding Specificity: N-Term

Purpose: HDAC7 Recombinant Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Recombinant human HDAC7 protein, around N-terminal 150aa.

Isotype: IgG

Application Details

Application Notes: WB(1:500-2000), IHC-P(1:50-200), IHC-F(1:50-200), IF(1:50-200), Flow-Cyt(1:50-200), ICC/IF(1:50-100)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for HDAC7

Target: HDAC7 (Histone Deacetylase 7 (HDAC7))

Alternative Name: HDAC7

Background:

Synonyms: Histone deacetylase 7, HDAC7

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).

Gene ID: 51564

UniProt: Q8WUI4

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development