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ARF1 antibody

ARF1 Reactivity: Human, Rat, Mouse WB, IF (cc) Host: Rabbit Monoclonal 1D4 unconjugated
Catalog No. ABIN5557419
  • Target See all ARF1 Antibodies
    ARF1 (ADP-Ribosylation Factor 1 (ARF1))
    Reactivity
    • 62
    • 40
    • 28
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 64
    • 13
    • 1
    Rabbit
    Clonality
    • 57
    • 21
    Monoclonal
    Conjugate
    • 34
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ARF1 antibody is un-conjugated
    Application
    • 33
    • 31
    • 22
    • 15
    • 13
    • 13
    • 10
    • 8
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))
    Purification
    Purified by Protein A.
    Immunogen
    Recombinant human ARF1 protein, full length.
    Clone
    1D4
    Isotype
    IgG
    Top Product
    Discover our top product ARF1 Primary Antibody
  • Application Notes
    WB 1:1000-2000
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C
    Expiry Date
    12 months
  • Target
    ARF1 (ADP-Ribosylation Factor 1 (ARF1))
    Alternative Name
    ARF1 (ARF1 Products)
    Background

    GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity, the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

    Synonyms: ADP-ribosylation factor 1, ARF1

    Gene ID
    375
    UniProt
    P84077
    Pathways
    Transition Metal Ion Homeostasis, Inositol Metabolic Process
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