ARF1 antibody
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- Target See all ARF1 Antibodies
- ARF1 (ADP-Ribosylation Factor 1 (ARF1))
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This ARF1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))
- Purification
- Purified by Protein A.
- Immunogen
- Recombinant human ARF1 protein, full length.
- Clone
- 1D4
- Isotype
- IgG
- Top Product
- Discover our top product ARF1 Primary Antibody
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- Application Notes
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WB 1:1000-2000
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C
- Expiry Date
- 12 months
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- Target
- ARF1 (ADP-Ribosylation Factor 1 (ARF1))
- Alternative Name
- ARF1 (ARF1 Products)
- Background
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GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity, the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
Synonyms: ADP-ribosylation factor 1, ARF1
- Gene ID
- 375
- UniProt
- P84077
- Pathways
- Transition Metal Ion Homeostasis, Inositol Metabolic Process
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