GLRB antibody (AA 23-160)

Catalog No. ABIN5611340

Product Details anti-GLRB Antibody

Target: GLRB (Glycine Receptor, beta (GLRB))

Binding Specificity: AA 23-160

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GLRB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (IHC), Flow Cytometry (FACS), Neutralization (Neut)

Purification: purified

Immunogen: Purified recombinant fragment of human GLRB (AA: extra 23-160) expressed in E. coli.

Clone: 3B8A8

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400, IHC: N/A

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for GLRB

Target: GLRB (Glycine Receptor, beta (GLRB))

Alternative Name: GLRB (GLRB Products)

Synonyms: HKPX2 antibody, glrb antibody, MGC145156 antibody, AI853901 antibody, Glyrb antibody, spa antibody, spastic antibody, glrb2 antibody, zgc:101041 antibody, glycine receptor beta antibody, glycine receptor, beta antibody, glycine receptor, beta subunit antibody, glycine receptor, beta b antibody, GLRB antibody, Glrb antibody, glrb antibody, glrbb antibody

Background:

Description: This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.

Aliases: HKPX2

Molecular Weight: 56.1 kDa

Gene ID: 2743

HGNC: 2743