GLRB antibody (AA 180-260)

Catalog No. ABIN7221158

The Rabbit Polyclonal anti-GLRB antibody (ABIN7221158) specifically detects GLRB in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for GLRB antibody (AA 180-260) (ABIN7221158)

Target: GLRB (Glycine Receptor, beta (GLRB))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLRB antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-GLRB Antibody

Binding Specificity: AA 180-260

Purpose: Rabbit Anti-GlyRβ Polyclonal Antibody

Specificity: GlyRβ Polyclonal Antibody detects endogenous levels of GlyRβ protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human GlyRbeta at AA range: 180-260

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GLRB

Target: GLRB (Glycine Receptor, beta (GLRB))

Alternative Name: GlyRbeta

Background: GLRB, Glycine receptor subunit beta, Glycine receptor 58 kDa subunitGLRB encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.

Molecular Weight: 56kD

Gene ID: 2743

UniProt: P48167