SLC11A2 antibody (AA 1-65)

Catalog No. ABIN562043

There are 4+ publications for this product available. The Mouse Monoclonal anti-SLC11A2 antibody is suitable to detect SLC11A2 in samples from Human. It has been validated for WB, ELISA and IHC (p).

Quick Overview for SLC11A2 antibody (AA 1-65) (ABIN562043)

Target: SLC11A2 (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SLC11A2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4C6

Product Details anti-SLC11A2 Antibody

Binding Specificity: AA 1-65

Purpose: Mouse monoclonal antibody raised against a partial recombinant SLC11A2.

Sequence: MVLGPEQKMS DDSVSGDHGE SASLGNINPA YSNPSLSQSP GDSEEYFATY FNEKISIPEE EYSCF

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: SLC11A2 (NP_000608, 1 a.a. ~ 65 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-SLC11A2 antibody (ABIN562043)

Montalbetti, Simonin, Simonin, Awale, Reymond, Hediger: "Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2." in: Biochemical pharmacology, Vol. 96, Issue 3, pp. 216-24, (2015) (PubMed).

Montalbetti, Simonin, Dalghi, Kovacs, Hediger: "Development and Validation of a Fast and Homogeneous Cell-Based Fluorescence Screening Assay for Divalent Metal Transporter 1 (DMT1/SLC11A2) Using the FLIPR Tetra." in: Journal of biomolecular screening, Vol. 19, Issue 6, pp. 900-908, (2014) (PubMed).

Howitt, Putz, Lackovic, Doan, Dorstyn, Cheng, Yang, Chan-Ling, Silke, Kumar, Tan: "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 36, pp. 15489-94, (2009) (PubMed).

Foot, Dalton, Shearwin-Whyatt, Dorstyn, Tan, Yang, Kumar: "Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2." in: Blood, Vol. 112, Issue 10, pp. 4268-75, (2008) (PubMed).

Target Details for SLC11A2

Target: SLC11A2 (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2))

Alternative Name: SLC11A2

Background: Full Gene Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Synonyms: DCT1,DMT1,FLJ37416,NRAMP2

Gene ID: 4891

NCBI Accession: NM_000617

Pathways: Transition Metal Ion Homeostasis, Proton Transport, Positive Regulation of Endopeptidase Activity