SPRY2 antibody (AA 1-315)

Catalog No. ABIN564439

This Mouse Monoclonal antibody specifically detects SPRY2 in WB, ELISA, IF and IHC (p). It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for SPRY2 antibody (AA 1-315) (ABIN564439)

Target: SPRY2 (Sprouty Homolog 2 (SPRY2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SPRY2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1E10

Product Details anti-SPRY2 Antibody

Binding Specificity: AA 1-315

Purpose: Mouse monoclonal antibody raised against a full length recombinant SPRY2.

Sequence: MEARAQSGNG SQPLLQTPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQHSQVH SSARAPLSRS ISTVSSGSRS STRTSTSSSS SEQRLLGSSF SSGPVADGII RVQPKSELKP GELKPLSKED LGLHAYRCED CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC CKVPTVPPRN FEKPT

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: SPRY2 (AAH15745.1, 1 a.a. ~ 315 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-SPRY2 antibody (ABIN564439)

Ordóñez-Morán, Irmisch, Barbáchano, Chicote, Tenbaum, Landolfi, Tabernero, Huelsken, Muñoz, Pálmer: "SPROUTY2 is a ?-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer." in: Oncogene, Vol. 33, Issue 15, pp. 1975-85, (2014) (PubMed).

Moghaddam, Amini, Wei, Pourgholami, Morris: "Initial report on differential expression of sprouty proteins 1 and 2 in human epithelial ovarian cancer cell lines." in: Journal of oncology, Vol. 2012, pp. 373826, (2012) (PubMed).

Barbáchano, Ordóñez-Morán, García, Sánchez, Pereira, Larriba, Martínez, Hernández, Landolfi, Bonilla, Pálmer, Rojas, Muñoz: "SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity." in: Oncogene, Vol. 29, Issue 34, pp. 4800-13, (2010) (PubMed).

Target Details for SPRY2

Target: SPRY2 (Sprouty Homolog 2 (SPRY2))

Alternative Name: SPRY2

Background: Full Gene Name: sprouty homolog 2 (Drosophila)
Synonyms: MGC23039,hSPRY2

Gene ID: 10253

Pathways: EGFR Signaling Pathway, Sensory Perception of Sound, EGFR Downregulation