Hexokinase 2 antibody (AA 460-497)

Catalog No. ABIN5647143

This Rabbit Polyclonal antibody specifically detects Hexokinase 2 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Hexokinase 2 antibody (AA 460-497) (ABIN5647143)

Target: Hexokinase 2 (HK2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Hexokinase 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Hexokinase 2 Antibody

Binding Specificity: AA 460-497

Purification: Antigen affinity purified

Immunogen: Amino acids 460-497 (AYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMER-human) were used as the immunogen for the Hexokinase II antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Hexokinase II antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Hexokinase II antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Hexokinase 2

Target: Hexokinase 2 (HK2)

Alternative Name: Hexokinase 2

Background: Hexokinase II, also known as HK2, is an enzyme which in humans is encoded by the HK2 gene on chromosome 2. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase ii/2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

UniProt: P52789

Pathways: PI3K-Akt Signaling, Carbohydrate Homeostasis, Warburg Effect