APC2 antibody (AA 51-90)

Catalog No. ABIN5647467

This Rabbit Polyclonal antibody specifically detects APC2 in WB. It exhibits reactivity toward Human.

Quick Overview for APC2 antibody (AA 51-90) (ABIN5647467)

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-APC2 Antibody

Binding Specificity: AA 51-90

Purpose: APC2 Antibody

Sequence: KHLQGKLEQE ARVLVSSGQT EVLEQLKALQ MDITSLYNLK

Purification: Antigen affinity

Immunogen: Amino acids 51-90 (KHLQGKLEQEARVLVSSGQTEVLEQLKALQMDITSLYNLK) from the human protein were used as the immunogen for the APC2 antibody.

Isotype: IgG

Application Details

Application Notes: Differences in protocols and secondary/substrate sensitivity may require the APC2 antibody to be titrated for optimal performance.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the APC2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for APC2

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Alternative Name: APC2

Background: APC2, also called APCL or Adenomatous polyposis coli protein-like, is a deduced 2,303-amino acid protein that contains an N-terminal coiled-coil domain, followed by an armadillo domain and five 20-amino acid repeats. The human APC2 gene is mapped to chromosome 19p13.3. It is found that the 20-amino acid repeat domain of APCL could bind beta-catenin (CTNNB1) and deplete the intracellular beta-catenin pool. A reporter gene assay revealed that APCL could regulate interaction of beta-catenin with T cell-specific transcription factors (TCF7), although less efficiently than APC.

UniProt: O95996

Pathways: WNT Signaling