APC2 antibody (AA 51-90)

Catalog No. ABIN5647467

Product Details anti-APC2 Antibody

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Binding Specificity: AA 51-90

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity purified

Immunogen: Amino acids 51-90 (KHLQGKLEQEARVLVSSGQTEVLEQLKALQMDITSLYNLK) from the human protein were used as the immunogen for the APC2 antibody.

Isotype: IgG

Application Details

Application Notes: Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the APC2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for APC2

Target: APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))

Alternative Name: APC2 (APC2 Products)

Synonyms: APCL antibody, AI852447 antibody, R75424 antibody, APC2, WNT signaling pathway regulator antibody, adenomatosis polyposis coli 2 antibody, APC2 antibody, Apc2 antibody

Background: APC2, also called APCL or Adenomatous polyposis coli protein-like, is a deduced 2,303-amino acid protein that contains an N-terminal coiled-coil domain, followed by an armadillo domain and five 20-amino acid repeats. The human APC2 gene is mapped to chromosome 19p13.3. It is found that the 20-amino acid repeat domain of APCL could bind beta-catenin (CTNNB1) and deplete the intracellular beta-catenin pool. A reporter gene assay revealed that APCL could regulate interaction of beta-catenin with T cell-specific transcription factors (TCF7), although less efficiently than APC.

UniProt: O95996

Pathways: WNT Signaling