ASIC3 antibody (AA 55-83)

Catalog No. ABIN7479754

This Rabbit Polyclonal antibody specifically detects ASIC3 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for ASIC3 antibody (AA 55-83) (ABIN7479754)

Target: ASIC3 (ACCN3) (Amiloride-Sensitive Cation Channel 3 (ACCN3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASIC3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ASIC3 Antibody

Binding Specificity: AA 55-83

Purpose: ASIC3 Antibody / ACCN3

Purification: Antigen affinity

Immunogen: A portion of amino acids 55-83 from the human protein was used as the immunogen for this ASIC3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the ASIC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the ASIC3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for ASIC3

Target: ASIC3 (ACCN3) (Amiloride-Sensitive Cation Channel 3 (ACCN3))

Alternative Name: ASIC3

Background: This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1/ASIC2 has been observed as proton-gated channels sensitive to gadolinium. Alternative splicing of this gene generates three transcript variants encoding distinct isoforms.

UniProt: Q9UHC3