SYK antibody (pTyr525, pTyr526)

Catalog No. ABIN7676197

The Rabbit Polyclonal anti-SYK antibody (ABIN7676197) specifically detects SYK in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for SYK antibody (pTyr525, pTyr526) (ABIN7676197)

Target: SYK (Spleen tyrosine Kinase (SYK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SYK Antibody

Binding Specificity: pTyr525, pTyr526

Purpose: Phospho-Syk Antibody (pY525/526)

Cross-Reactivity (Details): Expected species reactivity: Mouse,Rat,Pig

Purification: Antigen affinity

Immunogen: This phospho-Syk antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to the amino acid residues surrounding pY525/526 of human Syk.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the phospho-Syk antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the phospho-Syk antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for SYK

Target: SYK (Spleen tyrosine Kinase (SYK))

Alternative Name: Syk

Background: Syk is a positive effector of BCR-stimulated responses. This protein couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion.

UniProt: P43405

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling