TARDBP antibody (AA 1-260)

Catalog No. ABIN565079

The Mouse Polyclonal anti-TARDBP antibody has been validated for WB and ELISA. It is suitable to detect TARDBP in samples from Human. There are 5+ publications available.

Quick Overview for TARDBP antibody (AA 1-260) (ABIN565079)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This TARDBP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TARDBP Antibody

Binding Specificity: AA 1-260

Purpose: Mouse polyclonal antibody raised against a partial recombinant TARDBP.

Sequence: MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: TARDBP (NP_031401.1, 1 a.a. ~ 260 a.a) partial recombinant protein with GST tag.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 50 % glycerol

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-TARDBP antibody (ABIN565079)

Ayala, Granado-Serrano, Cacabelos, Naudí, Ilieva, Boada, Caraballo-Miralles, Lladó, Ferrer, Pamplona, Portero-Otin: "Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS." in: Acta neuropathologica, Vol. 122, Issue 3, pp. 259-70, (2011) (PubMed).

Tatom, Wang, Dayton, Skalli, Hutton, Dickson, Klein: "Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 17, Issue 4, pp. 607-13, (2009) (PubMed).

Schwab, Arai, Hasegawa, Akiyama, Yu, McGeer: "TDP-43 pathology in familial British dementia." in: Acta neuropathologica, Vol. 118, Issue 2, pp. 303-11, (2009) (PubMed).

Johnson, McCaffery, Lindquist, Gitler: "A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 17, pp. 6439-44, (2008) (PubMed).

Schwab, Arai, Hasegawa, Yu, McGeer: "Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease." in: Journal of neuropathology and experimental neurology, Vol. 67, Issue 12, pp. 1159-65, (2008) (PubMed).

Target Details for TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Alternative Name: TARDBP

Background: Full Gene Name: TAR DNA binding protein
Synonyms: ALS10,TDP-43

Gene ID: 23435

NCBI Accession: NM_007375

Pathways: Positive Regulation of Peptide Hormone Secretion