RRM2B antibody (AA 3-84)

Catalog No. ABIN565482

Cited in 2+ publications. The Mouse Monoclonal anti-RRM2B antibody (Clone 6C1) (ABIN565482) specifically detects RRM2B in WB, ELISA and IF. The antibody is reactive with Human samples.

Quick Overview for RRM2B antibody (AA 3-84) (ABIN565482)

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RRM2B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: 6C1

Product Details anti-RRM2B Antibody

Binding Specificity: AA 3-84

Purpose: Mouse monoclonal antibody raised against a partial recombinant RRM2B.

Sequence: DPERPEAAGL DQDERSSSDT NESEIKSNEE PLLRKSSRRF VIFPIQYPDI WKMYKQAQAS FWTAEEVDLS KDLPHWNKLK AD

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: RRM2B (NP_056528, 3 a.a. ~ 84 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-RRM2B antibody (ABIN565482)

Park, Kim, Piao, Kang, Park, Kim, Lee: "p53R2 regulates thioredoxin reductase activity through interaction with TrxR2." in: Biochemical and biophysical research communications, Vol. 482, Issue 4, pp. 706-712, (2016) (PubMed).

Piao, Jin, Kim, Lee, Amatya, Hyun, Chang, You: "Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2." in: Oncogene, Vol. 28, Issue 21, pp. 2173-84, (2009) (PubMed).

Target Details for RRM2B

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Alternative Name: RRM2B

Background: Full Gene Name: ribonucleotide reductase M2 B (TP53 inducible)
Synonyms: DKFZp686M05248,MGC102856,MGC42116,p53R2

Gene ID: 50484

NCBI Accession: NM_015713

Pathways: p53 Signaling, Negative Regulation of intrinsic apoptotic Signaling