HERC5 antibody (AA 915-1024)

Catalog No. ABIN565561

This Mouse Polyclonal antibody specifically detects HERC5 in WB and ELISA. It exhibits reactivity toward Human and has been mentioned in 4+ publications.

Quick Overview for HERC5 antibody (AA 915-1024) (ABIN565561)

Target: HERC5 (Hect Domain and RLD 5 (HERC5))

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This HERC5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-HERC5 Antibody

Binding Specificity: AA 915-1024

Purpose: Mouse polyclonal antibody raised against a partial recombinant HERC5.

Sequence: YDWKTFEKNA RYEPGYNSSH PTIVMFWKAF HKLTLEEKKK FLVFLTGTDR LQMKDLNNMK ITFCCPESWN ERDPIRALTC FSVLFLPKYS TMETVEEALQ EAINNNRGFG

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: HERC5 (NP_057407, 915 a.a. ~ 1024 a.a) partial recombinant protein with GST tag.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 50 % glycerol

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-HERC5 antibody (ABIN565561)

Im, Yoo, Hyun, Shin, Chung: "Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin." in: Open biology, Vol. 6, Issue 8, (2016) (PubMed).

Park, Yoon, Kim, Kim: "90K Glycoprotein Promotes Degradation of Mutant β-Catenin Lacking the ISGylation or Phosphorylation Sites in the N-terminus." in: Neoplasia (New York, N.Y.), Vol. 18, Issue 10, pp. 618-625, (2016) (PubMed).

Woods, Tong, Tom, Szabo, Cavanagh, Dikeakos, Haeryfar, Barr: "Interferon-induced HERC5 is evolving under positive selection and inhibits HIV-1 particle production by a novel mechanism targeting Rev/RRE-dependent RNA nuclear export." in: Retrovirology, Vol. 11, pp. 27, (2014) (PubMed).

Woods, Kelly, Hattlmann, Tong, Xu, Coleman, Quest, Smiley, Barr: "Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag." in: Retrovirology, Vol. 8, pp. 95, (2011) (PubMed).

Target Details for HERC5

Target: HERC5 (Hect Domain and RLD 5 (HERC5))

Alternative Name: HERC5

Background: Full Gene Name: hect domain and RLD 5
Synonyms: CEB1,CEBP1

Gene ID: 51191

NCBI Accession: NM_016323