MBD3 antibody (AA 1-255)

Catalog No. ABIN5664025

The Rabbit Polyclonal anti-MBD3 antibody is suitable to detect MBD3 in samples from Human. It has been validated for WB.

Quick Overview for MBD3 antibody (AA 1-255) (ABIN5664025)

Target: MBD3 (Methyl-CpG Binding Domain Protein 3 (MBD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBD3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MBD3 Antibody

Binding Specificity: AA 1-255

Sequence: MERKSPSGKK FRSKPQLARY LGGSMDLSTF DFRTGKMLMS KMNKSRQRVR YDSSNQVKGK PDLNTALPVR QTASIFKQPV TKITNHPSNK VKSDPQKAVD QPRQLFWEKK LSGLNAFDIA EELVKTMDLP KGLQGVGPGC TDETLLSAIA SALHTSTMPI TGQLSAAVEK NPGVWLNTTQ PLCKAFMVTD EDIRKQEELV QQVRKRLEEA LMADMLAHVE ELARDGEAPL DKACAEDDDE EDEEEEEEEP DPDPE

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human MBD3 (NP_001268383.1).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MBD3

Target: MBD3 (Methyl-CpG Binding Domain Protein 3 (MBD3))

Alternative Name: MBD3

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene.,MBD3,Epigenetics & Nuclear Signaling,MBD3

Molecular Weight: 29 kDa/32 kDa

Gene ID: 53615

UniProt: O95983

Pathways: Chromatin Binding