Recombinant Polysialic Acid antibody
Reactivity: Human, Mouse, Rat
FACS, IHC, IP
Host: Rabbit
Chimeric
735
unconjugated
Recombinant Antibody
-
- Target
- Polysialic Acid
- Antibody Type
- Recombinant Antibody
- Reactivity
- Human, Mouse, Rat
-
Host
- Rabbit
-
Clonality
- Chimeric
-
Conjugate
- Un-conjugated
- Application
- Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Specificity
- Recognises Polysialic acid (PSA), a carbohydrate polymer attached to the neural cell adhesion molecule (NCAM), which shares molecular epitopes with homopolymers of α2,8-linked sialic acid of Escherichia coli K1.
- Characteristics
-
OriginalSpeciesName: Mouse
OriginalFormat: IgG2a
- Purification
- Purified antibody.
- Immunogen
- Homopolymers of alpha2,8-linked sialic acid of Escherichia coli K1.
- Clone
- 735
- Isotype
- IgG kappa
-
-
- Application Notes
- This antibody recognises an unusual postranslational modification on neural cell adhesion molecules important in synaptogenesis, oncogenesis (particularly small-cell lung cancer) and development of organs such as the kidney (studied in rats, Lackie et al. 1990). In addition to various studies on human cells, the antibody, has also been used the study the fine-composition of poly-sialic acid composition in mice (Galuska et al. 2006).
- Comment
-
This chimeric rabbit antibody was made using the variable domain sequences of the original murine IgG2a format, for improved compatibility with existing reagents, assays and techniques.
- Restrictions
- For Research Use only
-
- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
-
- Target
- Polysialic Acid
- Background
- PSA, N-CAM, neural cell adhesion molecule, polySA
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