Recombinant TNF alpha (Humicade Biosimilar) antibody

Catalog No. ABIN5668144

The Rabbit Chimeric anti-TNF alpha (Humicade Biosimilar) antibody (Clone CDP 571) (ABIN5668144) specifically detects TNF alpha (Humicade Biosimilar) in ELISA and Neut. The antibody is reactive with Human samples.

Quick Overview for Recombinant TNF alpha (Humicade Biosimilar) antibody (ABIN5668144)

Target: TNF alpha (Humicade Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: Un-conjugated

Application: ELISA, Neutralization (Neut)

Clone: CDP 571

Product Details

Purpose: Anti-TNF alpha [CDP 571 (Humicade)], Rabbit IgG, kappa

Specificity:

The antibody binds to human TNF-alpha with a Kd of 0.087 nM.

Application Notes original Clone: The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB.

Characteristics: NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.

Purification: Protein A affinity purified

Purity: > 98 % as determined by SDS-PAGE

Endotoxin Level: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: Human TNF-alpha

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

OriginalSpeciesName: Human

OriginalFormat: IgG4

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details

Target: TNF alpha (Humicade Biosimilar)

Target Type: Biosimilar

Background: TNFA, Tumour necrosis factor superfamily member 2, TNFSF2

UniProt: P01375