Recombinant TNF alpha (Humicade Biosimilar) antibody
Quick Overview for Recombinant TNF alpha (Humicade Biosimilar) antibody (ABIN7487761)
Target
Antibody Type
Reactivity
Host
Clonality
Conjugate
Application
Clone
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Purpose
- Anti-TNF alpha [CDP 571 (Humicade)], Mouse IgG1, kappa
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Specificity
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The antibody binds to human TNF-alpha with a Kd of 0.087 nM.
Application Notes original Clone: The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB.
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Characteristics
- NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
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Purification
- Protein A affinity purified
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Immunogen
- Human TNF-alpha
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Isotype
- IgG1, kappa
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anti-TNF alpha (Humicade Biosimilar) antibody
Reactivity: Human ELISA, Neut Host: Human Monoclonal CDP 571 unconjugated Recombinant Antibody
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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OriginalSpeciesName: Human
OriginalFormat: IgG4
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Restrictions
- For Research Use only
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Concentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % Proclin 300.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- TNF alpha (Humicade Biosimilar)
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Target Type
- Biosimilar
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Background
- TNFA, Tumour necrosis factor superfamily member 2, TNFSF2
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UniProt
- P01375
Target
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