Recombinant CD11b antibody

Catalog No. ABIN5668175

This Mouse Monoclonal antibody specifically detects CD11b in FACS and ELISA. It exhibits reactivity toward Human.

Quick Overview for Recombinant CD11b antibody (ABIN5668175)

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD11b antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA

Clone: 107

Product Details anti-CD11b Antibody

Purpose: Anti-Integrin α-M [107], Mouse IgG1, kappa

Specificity: This antibody binds to the MIDAS face of the A domain from integrin CD11b.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: Wild type (WT) recombinant CD11b.

Isotype: IgG1 kappa

Application Details

Application Notes: The antibody binds specifically to integrin α-M, a protein subunit of the α-M- β-2 Molecule, which is expressed on the surface of leukocytes. Integrin α-M is involved in the adhesive interaction between molecules of the innate immune system, and plays a role in the uptake of complement-coated particles. The monoclonal antibody 107 has a blocking activity by binding to the metal-ion-dependent-adhesion site, favouring a low affinity conformation of the antigen.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Alternative Name: Integrin alpha-M

Background: CD11b, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, leukocyte adhesion receptor MO1, Neutrophil adherence receptor, complement receptor 3

UniProt: P11215

Pathways: Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation